Key Discoveries in the Therapeutic Application of Cord Blood:
Improvement of Motor Function in Children with Cerebral Palsy
WALTHAM, Mass.--(BUSINESS WIRE)--
published in Stem Cells Translational Medicine shows
encouraging developments related to using a child's own cord
blood to treat childhood brain injury known as cerebral palsy (CP).
The research from a Phase II clinical trial indicates that patients with
CP who were treated with an infusion of an adequate dose of their own
cord blood, which had been collected and stored at birth, saw a
significant improvement in their motor function. Of the 63 children
receiving treatment, those who were given a dose higher than 20 million
cells per kilogram showed improvements in motor function measured on a
validated scale for assessing motor function in children with CP called
the Gross Motor Function Measure (GMFM-66).
"This is the first demonstration of a therapy producing durable
improvements in motor function in young children with CP. We are very
encouraged by these results. Our research has indicated that autologous
cord blood infusions are feasible, safe and easily administered in the
outpatient setting," said Joanne Kurtzberg, MD, Director, Carolinas Cord
Blood Bank and Pediatric Blood and Marrow Transplant Program; Chief
Scientific Officer, Robertson Clinical and Translational Cell Therapy
Program, Duke University, who led the clinical trial.
The purpose of this Phase II trial was to determine the efficacy of
using a child's own (autologous) cord blood for the treatment of
pediatric patients with cerebral palsy. The primary measure of efficacy
was a significant change in standardized measure of motor function over
what would have been expected at one year without the treatment. Further
details can be found here.
"Before our son Patrick's cord blood treatment, things were so
overwhelming for him and our family. Patrick struggled with therapy,
school and the normal daily activities you take for granted," said GiGi
and Kevin Rooney, the parents of a child who participated in the study.
"Today, after his cord blood treatment, Patrick has great stamina and
endurance and the confidence to try new things. Having his cord blood
and being in this study has tremendously impacted our lives for the
better and we are truly grateful."
These findings in children with CP follow the publication in April 2017
of results from a Phase I trial testing the safety of using a child's
own cord blood to treat Autism
Spectrum Disorder (ASD) published in Stem Cells Translational Medicine.
Duke continues to study the use of cord blood to treat children with
Autism Spectrum Disorder in a Phase II Clinical Trial using both
autologous and allogeneic cord blood, and recently completed a Phase I
study in children with CP who were treated with cord blood from a
"For more than 20 years, ViaCord has collaborated on projects to
determine the clinical utility of cord blood stem cells. These initial
findings mark an exciting development in the potential use of cord blood
stem cells for treating Cerebral Palsy, and a significant step in
establishing the role of cord blood beyond transplant medicine and into
regenerative medicine, including Autism," said Morey Kraus, Chief
Scientific Officer, ViaCord. "We are proud that ViaCord families were
able to participate in this historic study by having access to their own
cord blood, and we look forward to helping many more families."
ViaCord, PerkinElmer's (NYSE:PKI) cord blood and cord tissue
preservation business, has preserved the umbilical cord stem cells of
more than 350,000 newborns and released over 350 cord blood units for
treatment and clinical research studies. It has released more than 200
cord blood units for use in the treatment of nearly 80 diseases
including acute lymphoblastic leukemia and sickle cell disease and more
than 150 cord blood units for use in clinical research studies including
this study for Cerebral Palsy and Autism Spectrum Disorder.
Please visit www.viacord.com
for more information. Follow ViaCord on Twitter @ViaCord.
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Elizabeth Tripp, 646-556-9324
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